Date of Birth: 1963
Place of Birth: Cape Town, South Africa

EDUCATION

Graduate 1/89-12/89	University of Cape Town Medical School South Africa Degree: B. Sc. (Hon)
Undergraduate 2/82-12/87	University of Cape Town Medical School South Africa Degree: M.B., Ch.B. Degree awarded with distinction in the clinical examinations

Principal Investigator - STAMINA Trial - Study of anemia in a heart failure population - observational heart failure registry study.

Sub-Investigator - CLARITY Trial - Clopidogrel as adjunctive reperfusion therapy - thrombolysis in MI - TIMI 28

Sub-Investigator - ATTACH Trial - Assessment of Toprol XL taken in combination with hydrochlorothiazide. (2003-2004)

Sub-Investigator - Early ACS (2004)

Principal Investigator - Re-Ly (2006)

Sub-Investigator - IMPROVE-IT (2006)

Sub-Investigator - Durability (start 2007)

BIBLIOGRAPHY

ORIGINAL REPORTS

Stein B, Takizawa M, Katz I, Joffe I, Berlin J, Fallon M, Epstein S: "Salmon Calcitonin Prevents Cyclosporin-A-Induced High Turnover Bone Loss." Endocrinology 129:92-8, 1991

Jacobs TW, Katz IA, Joffe II, Stein B, Takizawa M, Epstein S: "The Effect of FK506, Cyclosporin-A, and Cyclosporin-G on Serum 1,25-dihydroxy vitamin D Levels." Transplantation Procardia. 23:3200-1, 1991

Katz IA, Takizawa M, Joffe II, Stein B, Fallon MD, Epstein S: "Comparison of the Effects of FK506 on Bone Mineral Metabolism in the Rat. A Pilot Study." Transplantation 52(3):571-4, 1991

Joffe I, Katz I, Jacobs, T, Stein B, Takizawa M, Liu C, Berlin J, Epstein S: "17B Estradiol Prevents Osteopenia in the Oophorectomized Rat Treated with Cyclosporin A." Endocrinology 130:1578-86, 1992

Katz IA, Jee WSS, Joffe II, Stein B, Takizawa M, Jacobs TW, Setterberg R, Lin BY, Tank LY, Ke HZ, Zeng QQ, Berlin J, Epstein S: "Prostaglandin E2 Alleviates Cyclosporin A-Induced Bone Loss in the Rat." J. Bone Miner Res. 7(10):1191-200, 1992

Joffe I, Katz I, Sehgal S, Bex F, Kharode Y, Tamasi J, Epstein S: "Lack of Change of Cancellous Bone Volume with Short-Term Use of the New Immunosuppressant Rapamycin in Rats." Calcified Tissue Inter. 53:45-52, 1993

Katz I, Li M, Joffe I, Stein B, Jacobs T, Liang XG, Ke HZ, Jee W, Epstein S: "Influence of Age on Cyclosporin A-Induced Alterations in Bone Mineral Metabolism in the Rat in Vivo." J. Bone Miner Res. 9(1):59-67, 1994

Epstein S, Takizawa M, Stein B, Katz IA, Joffe II, Jacobs TW, Romero D, Liang XG, Li M, Ke HZ, Jee WSS, Berlin J: "The Effect of Cyclosporin A on Bone Mineral Metabolism in Experimental Diabetes Mellitus in the Rat." J. Bone Miner Res. 9:557-66, 1994

Joffe II, Lampert C, Jacobs LE, Owen AN, Ioli A, Kotler MN: "Cardiac Sarcoidosis Masquerading as a Metastatic Tumor: The Role of Transthoracic and Transesophageal Echocardiography." J. Am. Soc. Echocardiogr. 8:933-7, 1996

Joffe II, Jacobs LE, Owen AN, Ioli A, Kotler MN: "Mycotic Aneurysm of the Descending Thoracic Aorta: The Role of Transthoracic and Transesophageal Echocardiography." J. Am. Soc. Echocardiogr. 8:663-7, 1996

Joffe II, Jacobs LE, Kotler MN: "Pericardial Tamponade. Images in Cardiovascular Medicine." J. Am. Soc. Circulation 94:2667, 1996

Joffe II, Jacobs LE, Owen AN, Ioli A, Weiss SE, Nakhjavan FK, Mayer TG, Kotler MN: "Tricuspid papillary Muscle Rupture After Coronary Artery Bypass Surgery: Identification by Transesophageal Echocardiography." Am. Heart J. 132:1055-58, 1996

Joffe II, Douglas PS: "Cardiac Tamponade in Association with an Atrial Septal Defect: Echocardiographic Doppler and Hemodynamic Observations." J. Am. Soc. Echocardiogr. 9:909-14, 1996

Joffe II, Riley MF, Katz SE, Ginsburg GS, Douglas PS: "Acquired Dynamic Left Ventricular Outflow Tract Obstruction Complicating Acute Anterior Myocardial Infarction: Serial Echocardiographic and Clinical Evaluation." J. Am. Soc. Echocardiogr.,10:717-21, 1997

Joffe II, Travers KE, Perreault-Micale C, Hampton T, Katz SE, Morgan JP, Douglas PS: "Abnormal Cardiac Function in the Streptozotocin-Induced, Non-Insulin Dependent Diabetic Rat: Non-Invasive Assessment with Echocardiographic-Doppler and the Contribution of the Nitric Oxide Pathway." Journal American College of Cardiology, 34:2111-9, 1999.

REVIEWS AND EDUCATIONALLY RELEVANT PUBLICATIONS

Joffe I, Epstein S: "Osteoporosis Associated with Rheumatoid Arthritis: Pathogenesis and Management." Seminars Arthritis Rheum. 20:256-72, 1991

Joffe I: "Cigarette Smoking and Facial Wrinkling." Ann. Intern. Med. 115:659, 1991 [Letter]

Joffe I: "The Emergence of Drug-Resistant Tuberculosis in New York City." New Engl. J. Med. 329:134, 1993 [Letter]

Joffe I: "Withdrawal of Digoxin from Patients with Chronic Heart Failure Treated with Angiotensin-Converting-Enzyme Inhibitors." New Engl. J. Med. 329:1820, 1993 [Letter]

Joffe II, Lampert C, Jacobs LE, Kotler MN: "Atherosclerotic Disease of the Aortic Arch and the Risk of Stroke." New Engl. J. Med. 332:1237, 1995 [Letter]

Joffe, II. "Predictors of Systemic Embolism in Mitral Stenosis." Ann Intern Medication, 129:1077-8, 1998

Joffe II, Jacobs LE, Owen AN, Ioli A, Kotler MN: "Non-Infective Valvular Masses." Am. Heart J. 131:1175-83, 1996 [A review of the literature with emphasis on imaging techniques and management.)

Joffe II, Lampert C, Jacobs LE, Owen AN, Kotler MN: "AThe Role of Echocardiography in the Management of Patients Undergoing Open Heart Surgery." Am. Heart J. 131:162-76, 1996 [A review.]

Joffe II, Morgan JP: "Cardiac Evaluation of the Patient Undergoing Non-Cardiac Surgery." Up to Date 1995, 1996, 1997, 1998

Joffe II: "The Risk of Stroke in Atrial Fibrillation." Ann. Internal Medicine 1999

Joffe, II: "The Assessment of Cardiovascular Risk In Patients Undergoing Non-Cardiac Surgery." Up to Date 1997 -Present

ABSTRACTS

Adeleke KT, Owen AN, Ioli AW, Oliner CM, Kotler MN, Joffe II, Lampert C, Jacobs LE: "Can Atropine Requirement be Predicted Early During Dobutamine Stress Echocardiography?" J. Am. Soc. Echocardiogr. 1995 (Abstract)

Joffe II, Travers KE, Perreault-Micale CL, Hampton TG, Katz SE, Morgan JP, Douglas PS: "Impaired Nitric Oxide Availability Contributes to the Cardiac Dysfunction of Diabetes." Circulation 1997

Joffe II, Travers KE, Douglas PS: "Diabetes Contributes to the Adverse Remodeling Post-Infarction." J. Am. Soc. Echocard. 1999