Date of Birth: 1963

EDUCATION

8/1992	Case Western Reserve University Cleveland, OH Degree: Ph.D. - Physiology and Biophysics
8/1984	Fujian Medical College Fuzhou, Fujian, China Degree: M.D.

"Regulation of ATP-Induced Ca²⁺ Response by Protein Kinase A and Protein Kinase C in Adult Myocytes." Gerontology Research Center, National Institute of Aging, National Institutes of Health, October 17, 1991.

"ATP Receptors and Regulation of ATP-Induced Ca²⁺ Transients in Cardiac Myocytes." Department of Pharmacology, University of California at San Diego, November 25, 1992.

"Signal Transduction by Extracellular ATP in Cardiac Myocytes." Department of Medicine, Washington University, December 22, 1992.

"Atherosclerosis: A Multifactorial Disease." Fujian Provincial Research Institute for Cardiovascular Diseases, Fuzhou, Fujian, China, April 11, 1994.

"Mechanism of Chronic Heart Failure in Hypertrophied Rat." Fujian Provincial Hospital, Fujian, China, April 12, 1994.

"Mechanism of Cardiac Hypertrophy." Annual Conference of Fujian Provincial Research Institute of Cardiovascular Diseases, Fuzhou, Fujian, China, April 13, 1994.

"Intracellular and Molecular Mechanism of Cardiac Hypertrophy and Heart Failure." Department of Medicine, The Affiliated No. 1 Hospital, Xian Medical University, April 18, 1994.

"Alteration of Gene Expression in Chronic Heart Failure Rat." Department of Medicine, Institute of Cardiovascular Disease, Tongji Medical University, April 25, 1994.

"Extracellular ATP Inhibits NE- or PE-Induced Cardiac Hypertrophy in Neonatal Cardiac Myocytes." Department of Biology, Beijing Medical University, April 29, 1994.

"Treatment of Acute Myocardial Infarction." Fujian Medical College and Fujian Union Hospital, April 4, 2001.

"Heart Transplant: Preoperative Selection and Postoperative Management." Fujian Heart Association, China, April 6, 2001.

"Update of Acute Myocardial Infarction Management." Weifang Medical College, Weifang Heart Association, April 17, 2001.

"ACC/AHA Guideline for Management of Acute Myocardial Infarction." Fuzhou Second Hospital, April 24, 2001.

CME LECTURE

"Essential Thrombocytopenia." Department of Medicine, Providence Hospital - George Washington University, September 4, 1997.

GRAND ROUNDS

Atrial Fibrillation Update. Temple University Hospital, Philadelphia, PA, June 19, 2002

Zhang SS, Zheng JS, Hu XZ, Guo G, Lin HP, Xue BC, Chen TS: "Echocardiographic Characterization of Hypertrophic Cardiomyopathy: A Report of 16 Cases." Thesis Collection in 3rd Session of Cardiovascular Meeting 56-61, 1988

Zheng JS, DeYoung MB, Wiener E, Levy MN, Scarpa A: "Extracellular ATP-Induced Ca²⁺ Transients in Cardiac Myocytes are Potentiated by an Increase in Cellular cAMP." Ann. N.Y. Acad. Sci. 603:448-451, 1990

Zheng JS, Christie A, DeYoung MB, Levy MONITOR, Scarpa A: "Synergism Between Cyclic AMP and ATP in Signal Transduction in Cardiac Myocytes." Am. J. Physiol. 262 (Cell Physiol.): C128-C135, 1992

Zheng JS: "APT Receptors and Regulation of the ATP-Induced Ca²⁺ Mobilization Response in Cardiac Myocytes." (Ph.D. Thesis)

Zheng JS, Christie A, Levy MN, Scarpa A: "Ca²⁺ Mobilization by Extracellular ATP in Rat Cardiac Myocytes: Regulation by Protein Kinase C and A." Am. J. Physiol. 263 (Cell Physiol. 32): C933-C940, 1992

Zheng JS, Christie A, Levy MN, Scarpa A: "Modulation of Two Distinct Currents by Extracellular ATP in Isolated Rat Myocytes." Am. J. Physiol. 264 (Cell Physiol. 33): C1411-C1417, 1993

Zheng JS, Boluyt MO, O'Neill L, Crow MT, Lakatta EG: "Extracellular ATP Induces Immediate-Early Gene Expression but not Cellular Hypertrophy in Neonatal Cardiac Myocytes." Circ. Res. 74:1034-1041, 1994

Zheng JS, Boluyt MO, O'Neill L, Long X, Lakatta EG, Crow MT: "Extracellular ATP inhibits Adrenergic-Induced Hypertrophy of Neonatal cardiac Myocytes." Circ. Res. 78:525-535, 1996

Zheng JS, Boluyt MO, Dai J Li, Long X, Baum B, Lakatta EG Crow MT: "Expression of the AQP-CHIP Water Channel in Rat Heart." Asian Pacific Heart J. 8(1), 1999

Boluyt MO, Zheng JS, Young A, Long X, O'Neill L, Silverman H, Lakatta EG, Crow MT: "Rapamycin Inhibits Cellular Hypertrophy in Cultured Neonatal Rat Cardiac Myocytes." Circ. Res. 81:176-186, 1997

Long X, Boluyt MO, O'Neill L, Zheng JS, Lakatta EG, Crow MT: "Myocardial Retinoid X Receptor, Thyroid Hormone Receptor, and Myosin Heavy Chain Gene Expression in the Rat During Adult." J. Geron. (Biol. Sci) 54A (1): B23-B27, 1999

Long X, Boluyt MO, O'Neill L, Zheng JS, Crow MT, Lakatta EG: "Hypoxia-Induced Expression of Heme Oxygenase Gene in Neonatal Cardiac Myocytes." J. Biol. Chem. (In revision)

Long X, Boluyt MO, Hipolito MDL, Lundberg MS, Zheng JS, O'Neill LO, Cirielli C, Capogrossi M, Lakatta EG, Crow MT: "p53 and the Hypoxia-Induced Apoptosis of Cultured Rat Neonatal Cardiac Myocytes." J. Clin. Invest. 99 (11):2635-2643, 1997

Zheng JS, Boluyt MO, O'Neill L, Long X, Crow MT, Lakatta EG: "Induction of Immediate-Early Genes by Extracellular ATP is Mediated by Activation of P_2u-Receptors in the Neonatal Cardiac Fibroblasts." Cardiovasc. Res. 37:718-728, 1998

Boluyt MO, O'Neill L, Zheng JS, Meredith A, Lakatta EG, Crow MT: "Stimulation of Adrenergic Receptor Induces Preproenkephalin Gene Expression in Cardiac Myocytes and Non-Myocytes." (Submitted)

Zheng JS, O'Conor F, Edward EG, Fleg F: "Use Electrocardiogram Stress Test and Thallium Tomography to Predict Cardiac Events in Asymptomatic Volunteers." (In preparation)

Zheng JS, McNeal R, Sangligoli R, Rothman S: "Cardioversion of Atrial Fibrillation in the Patients with Left Ventricular Dysfunction of Heart Failure." (In preparation)

Zheng JS, DeYoung MB, Levy MN, Scarpa A: "Forskolin and Cyclic AMP Analogues Potentiate ATP-Induced Ca²⁺ Transients in Myocytes." The Physiologist 32(4): 48, 1989

Christie A, Zheng JS, Levy MN, Scarpa A: "Mechanism of Norepinephrine Enhancement of ATP-Induced Ca²⁺ Transients." Biophys. J. 57(2):129a, 1990

Zheng JS, Christie A, DeYoung MB, Levy MN, Scarpa A: "Effect of Protein Kinase C Activation on the ATP-Induced Ca²⁺ Response of Rat Ventricular Myocytes." Biophys. J. 59(2):224a, 1991

Zheng JS, Christie A, Levy MN, Scarpa A: "Extracellular ATP Elicits I_ATP and Increases I_Ca Through Different Mechanisms in Rat Ventricular Myocytes." FESAB J. 6(4):A978, 1992

Boluyt MO, O'Neill L, Zheng JS, Meredith A, Lakatta EG, Crow MT: "Adrenergic Receptor stimulation of Preproenkephalin Gene Expression in Cardiac Myocytes and Non-Myocytes." J. Cell. Biochem (Supp.) 17D:227, 1993

Zheng JS, Boluyt MO, O'Neill L, Meredith A, Crow MT, Lakatta EG: "Stimulation of P₂ Purinergic Receptors Increases c-fos, c-jun jun-B Gene Expression in Cultured Neonatal Cardiac Ventricular Myocytes." J. Cell. Biochem (Supp.) 17D:235, 1993

Zheng JS, Boluyt MO, Dai YS, Li J, Long XL, Baum BJ, Crow MT: "Expression of CHIP28 Water Channel in Aortic-Constricted Rat Heart." Circulation (Supp.) 88(4):I-232, 1993

Zheng JS, Boluyt MO, Ziman B, Long XL, O'Neill L, Crow MT, Lakatta EG: "Extracellular ATP Induces c-fos Gene Expression via a Ca²⁺-Dependent Pathway in Cultured Cardiac Myocytes and Fibroblasts." Circulation (Supp.) 88(4):I-92, 1993

Pauly RR, Monticone R, Sollot S, an Lakatta EG, Suzuki T, Crow MT: "The Intracellular Signaling Pathway for the PDGF-Induced Migration of Vascular Smooth Muscle Cells involves Ca²⁺-Calmodulin-Dependent Protein Kinase II." Circulation (Supp.) 88(4):I-4, 1993

Zheng JS, Boluyt MO, Song L, Adler WH, O'Neill L, Crow MT, Lakatta EG: "Extracellular ATP Activates Multiple Second Messenger Systems and Increases Immediate-Early Gene Expression in Cardiac Fibroblasts." The Physiologist 36:(5) A-15, October 1993

Crow MT, Pauly RR, Zheng JS, Lakatta EG: "The Intracellular Signaling Pathway for Vascular Smooth Muscle Cell Migration in Response to PDGF Involves Calcium/Calmodulin-dependent Protein Kinase II." The Physiologist 36:(5) A-18, October 1993

Zheng JS, Boluyt MO, O'Neill L, Long X, Lakatta EG, Crow MT: "Extracellular Adenosine Triphosphate (ATP) Inhibits Cardiac Myocytes Hypertrophy Induced by Adrenergic Agonist." Circulation (Supp.) 90(4):I-194, 1994

Boluyt MO, Zheng JS, Younes A, O'Neill L, Lakatta EG, Crow MT: "Inhibition of p70 S6 Kinase Inhibits αI-Adrenergic Receptors Stimulated Cardiomyocyte Hypertrophy." (1995 American College of Sports Medicine Annual Meeting)

Zheng JS, Boluyt MO, O'Neill L, Long X, Lakatta EG , Crow MT: "Extracellular ATP is a Potent Inhibitor of Hypertrophy in Neonatal Cardiac Myocytes." (American Heart Association Scientific Conference on the Molecular Cellular and Functional Aspects of Cardiovascular Development, New Orleans, LA, March 1995)

Long X, Boluyt MO, O'Neill L, Zheng JS, Lakatta EG, Crow MT: "Decreased Expression of Retinoid X Receptor Genes Correlates with Age-Associated Changes in Myosin Phenotype in Rat Heart." (American Heart Association Scientific Conference on the Molecular Cellular and Functional Aspects of Cardiovascular Development, New Orleans, LA, March 1995)

Zheng JS, O'Neill L, Long X, Boluyt MO: "Extracellular ATP-Induced c-fos mRNA and Activates Multiple Second Messenger Pathways via P2 Purinergic Receptors in Cardiac Fibroblasts." Circulation (Supp.) 92(8):I-573, 1995

Boluyt MO, Zheng JS, Younes A, O'Neill L, Crow MT: "p70/85 S6 Kinase Activation is Required for αI-Adrenergic Receptors Stimulated Hypertrophy in Neonatal Rat Cardiac Myocytes." Circulation (Supp.) 92(8):I-384, 1995

Boluyt MO, Zheng JS, Younes A, O'Neill L, Lakatta EG, Crow MT: "Rapamycin Selectively Inhibits Protein and RAN Accumulation, but not Induction of Hypertrophy-Associated Genes During Alpha-1 Adrenergic Stimulated Cardiac Myocyte Hypertrophy." Circulation (Supp.) 94(8):I-530, 1996